Use Caution/Monitor. nortriptyline increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Before using EpiPen, tell your doctor if any past use has caused an allergic reaction to get worse. Learn more about Epipen costs, generics and alternatives for treatment of severe life-threatening allergies (anaphylaxis): The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Contraindicated. Use Caution/Monitor. The underbanked represented 14% of U.S. households, or 18. Monitor Closely (3)epinephrine and metaproterenol both decrease serum potassium. Effect of interaction is not clear, use caution. Risk of acute hypertensive episode. Brand names include Contergan, Thalomid, Talidex, Talizer, Neurosedyn, Distaval and many others. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Before using EpiPen a second time, tell your doctor if your first injection caused a serious side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure). Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Use Caution/Monitor.epinephrine and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and amitriptyline both increase QTc interval. In November 1961, thalidomide was taken off the market due to massive pressure from the press and public. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Serious - Use Alternative (1)epinephrine will decrease the level or effect of iobenguane I 131 by Other (see comment). Monitor Closely (2)penbutolol decreases effects of epinephrine by pharmacodynamic antagonism. Serious - Use Alternative (1)dihydroergotamine intranasal, epinephrine. ephedrine and epinephrine both decrease serum potassium. Contraindicated. The EpiPen Auto-Injector (0.3 mg) is for patients who weigh 66 pounds or more (30 kilograms or more). Hypokalemia. Use Caution/Monitor. Monitor Closely (2)epinephrine and fenfluramine both decrease sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Coadministration may reduce nateglinide's hypoglycemic action. There is also a high risk that thalidomide can interfere with formation of various kinds of new blood cells, creating a risk of infection via neutropenia, leukopenia, and lymphopenia, and risks that blood will not clot via thrombocytopenia. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor (1)eucalyptus increases and epinephrine decreases sedation. Use Caution/Monitor. only. Consider selective beta 1 blocker (e.g., metoprolol). Use Caution/Monitor. Use Caution/Monitor.dobutamine and epinephrine both decrease sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Hypotension, tachycardia. The effects may wear off after 10 or 20 minutes. These medications may have some side effects. Contraindicated. Consider selective beta 1 blocker (e.g., metoprolol). propofol increases levels of epinephrine by unknown mechanism. Contraindicated. Contraindicated. Both drugs can cause metabolic acidosis. Modify Therapy/Monitor Closely. WebBreadcrumbs for search hits located in schedulesto make it easier to locate a search hit in the context of the whole title, breadcrumbs are now displayed in the same way (above the timeline) as search hits in the body of a title. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. epinephrine and pimozide both increase QTc interval. Do not store in the bathroom. Compare formulary status to other drugs in the same class. epinephrine and dexfenfluramine both decrease sedation. trimipramine, epinephrine. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. amiloride increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. 275 0 obj Effect of interaction is not clear, use caution. [1] It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of schizophrenia when treatment with a conventional antipsychotic alone has failed. methoxyflurane increases toxicity of epinephrine by Mechanism: unknown. Monitor Closely (3)arformoterol and epinephrine both decrease serum potassium. selegiline increases effects of epinephrine by pharmacodynamic synergism. Contraindicated. The exploration of the antiangiogenic and immunomodulatory activities of thalidomide has led to the study and creation of thalidomide analogs. Hypotension, tachycardia. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. Contraindicated. Controlled studies in pregnant women show no evidence of fetal risk. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use EpiPen only for the indication prescribed. Effect of interaction is not clear, use caution. aspirin/citric acid/sodium bicarbonate increases and epinephrine decreases serum potassium. Use Caution/Monitor. [6], Thalidomide was first marketed in 1957 in West Germany, where it was available over the counter. Monitor Closely (3)epinephrine and formoterol both decrease serum potassium. epinephrine and dextroamphetamine both decrease sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. About 70% are excreted via the urine, almost exclusively in form of its metabolites, and 30% via the faeces. Avoid or Use Alternate Drug. droperidol increases and epinephrine decreases sedation. quetiapine increases and epinephrine decreases sedation. thioridazine increases and epinephrine decreases sedation. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Information last revised October 2021. ketoprofen increases and epinephrine decreases serum potassium. Canada residents can call a provincial poison control center. Interaction more likely in certain predisposed pts. Other (see comment). chlorpromazine increases and epinephrine decreases sedation. Consider selective beta 1 blocker (e.g., metoprolol). Use Caution/Monitor.ephedrine, epinephrine. Contraindicated. Monitor Closely (1)epinephrine decreases effects of nateglinide by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. By clicking send, you acknowledge that you have permission to email the recipient with this information. Use Caution/Monitor.esmolol decreases effects of epinephrine by pharmacodynamic antagonism. Risk of V tach, HTN. [29][30], Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. Use Caution/Monitor. Monitor Closely (1)butabarbital increases and epinephrine decreases sedation. Use Caution/Monitor.epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Also, make sure a family member, caregiver, or other responsible person knows where you keep this medication and how to use it in case you cannot inject the medication yourself. Avoid or Use Alternate Drug. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Remember to use it at the same times each day. epinephrine and chlorothiazide both decrease serum potassium. [40][41] It was first marketed as a drug to treat epilepsy in Switzerland in 1963 under the brand name "Tegretol"; its use for trigeminal neuralgia (formerly known as tic douloureux) was introduced at the same time. epinephrine, indapamide. Mechanism: pharmacodynamic synergism. If you are of childbearing age, use effective birth control methods while taking misoprostol and for at least one month or one completed menstrual cycle after you stop taking it. Monitor Closely (2)trimipramine increases effects of epinephrine by unknown mechanism. This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. Indicated to increase mean arterial blood pressure in adults with hypotension associated with septic shock, Recommended dose: 0.05-2 mcg/kg/minute IV infusion; titrate to desired mean arterial pressure (MAP); may adjust dose q10-15 min by 0.05-0.2 mcg/kg/minute to achieve desired blood pressure goal, After hemodynamic stabilization, may wean incrementally q30min over 12-24 hr, Indicated in emergency treatment of allergic reactions (Type I) including anaphylaxis, Unresponsive to atropine or pacing: 2-10 mcg//min by IV infusion or 0.1-0.5 mcg/kg/min (7-35 mcg/min in 70 kg patient); titrate to patient response, Induction and maintenance of mydriasis during intraocular surgery, Use only preservative-free vials without tartaric acid, 0.1 mg/mL solution: 0.01 mg/kg IO/IV q3-5min prn; not to exceed 1 mg/dose, 1 mg/mL solution: 0.1 mg/kg (0.1mL/kg) of endotracheal q3-5min prn; flush each dose with at least 5 mL 0.9% NaCl injection, Neonates (aged <28 days); 0.1 mg/mL solution: 0.01-0.03 mg/kg IVP (0.1-0.3 mL/kg) q3-5min; higher doses not recommended, Neonate IV access not available; 0.1 mg/mL solution: 0.05-0.1 mg/kg endotracheal tube; lower doses not effective; follow each dose with at least 5 mL 0.9% NaCl injection. alprazolam increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. epinephrine and ranolazine both increase QTc interval. Monitor Closely (1)clonazepam increases and epinephrine decreases sedation. It may harm an unborn baby. feeling restless, fearful, nervous, anxious, or excited. It is also used to prevent and treat nausea and vomiting after surgery. EpiPen pregnancy and breastfeeding warnings. triamterene increases and epinephrine decreases serum potassium. Minor/Significance Unknown. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). WebOlder adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Use Caution/Monitor.Minor (1)epinephrine, metolazone. Contraindicated. . Minor/Significance Unknown. A clinical trial studying the use of thalidomide in leprosy soon followed.[49]. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Get the latest health news, diet & fitness information, medical research, health care trends and health issues that affect you and your family on ABCNews.com Minor/Significance Unknown. Effect of interaction is not clear, use caution. Symptoms of overdose may include: severe drowsiness, seizures, severe dizziness, slow/irregular heartbeats. The usual maximum dose in patients with severe liver problems is 8 milligrams in 24 hours. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)meclofenamate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. acebutolol increases and epinephrine decreases serum potassium. You may need another dose of epinephrine if your symptoms do not get better, or if they return after one dose.Avoid injecting this medication into the hands, feet, buttocks, or areas of your body other than the thigh. Use Caution/Monitor. Use Caution/Monitor.acebutolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor.Minor (1)thiothixene decreases effects of epinephrine by pharmacodynamic antagonism. Monitor Closely (3)thioridazine, epinephrine. Other (see comment). Call your doctor for medical advice about side effects. "[45] Globally, more pharmaceutical companies started to produce and market the drug under license from Chemie Grnenthal. Monitor Closely (1)ketorolac intranasal increases and epinephrine decreases serum potassium. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. trifluoperazine increases and epinephrine decreases sedation. [7] Use in pregnancy may harm the fetus, including resulting in malformation of the limbs. Effect of interaction is not clear, use caution. Use Caution/Monitor. [40] It has been used as an anticonvulsant and antiepileptic in the UK since 1965, and has been approved in the US since 1968. Effect of interaction is not clear, use caution. Use Caution/Monitor. [citation needed] In 1956, researchers involved in clinical trials at SKF noted that, even when used in very high doses, thalidomide could not induce sleep in mice. Use Caution/Monitor. ),[77] and the Medicines Act 1968 (UK). Epipen (epinephrine injection) is given as an intramuscular (in the muscle) or subcutaneous (under the skin) injection only in the middle of the outer side of the thigh (the upper leg). Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and desipramine both increase QTc interval. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Monitor Closely (1)epinephrine decreases effects of insulin inhaled by pharmacodynamic antagonism. epinephrine and metaproterenol both decrease sedation. epinephrine and terbutaline both decrease serum potassium. Monitor Closely (1)epinephrine and trimethoprim both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)diphenhydramine increases and epinephrine decreases sedation. Use Caution/Monitor.epinephrine and epinephrine racemic both decrease sedation. epinephrine and azithromycin both increase QTc interval. Ask your doctor or pharmacist if you do not understand these instructions. epinephrine and furosemide both decrease serum potassium. Consult your doctor before breast-feeding. epinephrine and levalbuterol both decrease sedation. Use Caution/Monitor. Tell your doctor right away if any of these unlikely but serious side effects occur: menstrual problems or irregularities, unusual/heavy vaginal bleeding. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Use Caution/Monitor. Keep all medicines away from children and pets. WebFind patient medical information for Pepto-Bismol oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. [22], The precise mechanism of action for thalidomide is not known, although efforts to identify thalidomide's teratogenic action generated 2,000 research papers and the proposal of 15 or 16 plausible mechanisms by 2000. [28], Thalidomide is provided as a racemic mixture of two enantiomers; while there are reports that only one of the enantiomers may cause birth defects, the body converts each enantiomer into the other through mechanisms that are not well understood. thioridazine increases and epinephrine decreases sedation. Use Caution/Monitor. potassium chloride increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. nadolol increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)dipipanone increases and epinephrine decreases sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. These medications may have some side effects. Use Caution/Monitor.penbutolol decreases effects of epinephrine by pharmacodynamic antagonism. epinephrine and indapamide both increase QTc interval. Epinephrine may enhance hypotensive effects of lurasidone in overdose setting. There are more than 20 different types of anti-seizure medications available. Monitor Closely (3)epinephrine and terbutaline both decrease serum potassium. Effect of interaction is not clear, use caution. [56], Little further work was done with thalidomide in cancer until the 1990s. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. epinephrine and levofloxacin both increase QTc interval. epinephrine and pirbuterol both decrease sedation. epinephrine and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. meperidine increases and epinephrine decreases sedation. entacapone will increase the level or effect of epinephrine by decreasing metabolism. epinephrine and ziprasidone both increase QTc interval. ketamine, epinephrine. Monitor Closely (1)flurbiprofen increases and epinephrine decreases serum potassium. Monitor Closely (1)clorazepate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. WebMD does not provide medical advice, diagnosis or treatment. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. informational and educational purposes only. epinephrine and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. epinephrine and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. [10] The birth defects caused by thalidomide led to the development of greater drug regulation and monitoring in many countries. Effect of interaction is not clear, use caution. Monitor Closely (1)oxymorphone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. It is only for non-emergency use to practice giving yourself an injection. Interaction more likely in certain predisposed pts. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure. Effect of interaction is not clear, use caution. Epinephrine works quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat. Effect of interaction is not clear, use caution. albuterol and epinephrine both decrease serum potassium. oxymorphone increases and epinephrine decreases sedation. brompheniramine increases and epinephrine decreases sedation. After LASIK surgery, you're likely to experience side effects. What is the difference between Symjepi and EpiPen? [21] The (R)-enantiomer has the desired sedative effect while the (S)-enantiomer harbors embryo-toxic and teratogenic effect. ephedrine and epinephrine both decrease serum potassium. Monitor Closely (1)epinephrine and methyclothiazide both decrease serum potassium. azelastine increases and epinephrine decreases sedation. Do not store this medication in your vehicle or in the bathroom. arformoterol and epinephrine both decrease serum potassium. Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. Contraindicated. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)yohimbe, epinephrine. Monitor Closely (4)epinephrine, epinephrine racemic. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. codeine increases and epinephrine decreases sedation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Hypokalemia. Sue Kent, born in 1963 with phocomelia of both arms, eight inches long, no thumbs, and seven fingers three on one hand, four on the other - has appeared as a presenter on the BBC TV show "Gardener's World" since 2020, demonstrating her ability to garden using her feet and toes where others would use their hands. Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and perphenazine both increase QTc interval. Mechanism: unknown. Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)epinephrine, cyclopenthiazide. Effect of interaction is not clear, use caution. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor.betaxolol decreases effects of epinephrine by pharmacodynamic antagonism. clozapine increases and epinephrine decreases sedation. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Consider selective beta 1 blocker (e.g., metoprolol). [58] The results of that trial were published in the New England Journal of Medicine in 1999. Use Caution/Monitor. Monitor Closely (2)celiprolol decreases effects of epinephrine by pharmacodynamic antagonism. [58][64], It was also evaluated whether thalidomide can be combined with melphalan and prednisone for patients with multiple myeloma. morphine increases and epinephrine decreases sedation. Use Caution/Monitor. [6] While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus. Monitor Closely (1)phenoxybenzamine, epinephrine. Use Caution/Monitor. papaveretum increases and epinephrine decreases sedation. During pregnancy, this medication should be used only when clearly needed. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Serious - Use Alternative (1)epinephrine and fluconazole both increase QTc interval. Monitor Closely (1)opicapone will increase the level or effect of epinephrine by decreasing metabolism. Use Caution/Monitor. mefenamic acid increases and epinephrine decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor. only. piroxicam increases and epinephrine decreases serum potassium. Contraindicated. Effect of interaction is not clear, use caution. bisoprolol increases and epinephrine decreases serum potassium. Common side effects Serious - Use Alternative (1)levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Before taking misoprostol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. bretylium increases effects of epinephrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia.Serious - Use Alternative (1)epinephrine and promazine both increase QTc interval. Monitor Closely (1)epinephrine and serdexmethylphenidate/dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely. Use Caution/Monitor.epinephrine and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)entacapone will increase the level or effect of epinephrine by decreasing metabolism. Get emergency medical help if you have signs of an allergic reaction to Toprol-XL: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. penbutolol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated (1)epinephrine and pimozide both increase QTc interval. May increase risk for supine hypertension. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Mechanism: pharmacodynamic synergism. Accidentally injecting EpiPen into your hands or feet may result in a loss of blood flow to those areas, and resulting numbness. Dosage is based on your medical condition and response to therapy. Contraindicated. Effect of interaction is not clear, use caution. <>/Metadata 72 0 R>> The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making Monitor Closely (2)amoxapine increases effects of epinephrine by unknown mechanism. only. epinephrine and erythromycin stearate both increase QTc interval. Thalidomide can prevent menstruation. Use Caution/Monitor.epinephrine and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Assessment of Psychosis; Goals of Treatment for Psychosis; Pharmacological Treatment; Antipsychotic Medications; Antipsychotic Medication Side Effects; Other Medications That May Be Used; Barriers to Taking Medication; Psychosocial Treatments; Education; Stress Management and Living Well; Counselling and celiprolol increases and epinephrine decreases serum potassium. Contraindicated. Other (see comment). Minor/Significance Unknown. [6][9] Those who survived had limb, eye, urinary tract, and heart problems. Avoid or Use Alternate Drug.trimipramine, epinephrine. Epinephrine works quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Modify Therapy/Monitor Closely. Hypokalemia. ibuprofen increases and epinephrine decreases serum potassium. Use Caution/Monitor. ephedrine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)codeine increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor.epinephrine and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. loxapine increases and epinephrine decreases sedation. Use Caution/Monitor. It is available as an implant placed under the skin of the upper arm under the brand names Nexplanon and Implanon, and in combination with ethinylestradiol, an estrogen, as a vaginal ring under the brand names NuvaRing and Circlet. Use Caution/Monitor. desipramine increases and epinephrine decreases sedation. Use Caution/Monitor. It may take 6 to 12 hours before this medication causes a bowel movement . Other less common symptoms may include: nausea; abdominal cramps; diarrhea sulindac increases and epinephrine decreases serum potassium. epinephrine and diethylpropion both decrease sedation. Use Caution/Monitor.albuterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Why Is My Ulcerative Colitis Getting Worse? diflunisal increases and epinephrine decreases serum potassium. Additive vasospasm; risk of hypertension. Use Caution/Monitor. These health conditions include both physical and psychological conditions. Monitor Closely (1)epinephrine and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.Serious - Use Alternative (1)propranolol increases effects of epinephrine by pharmacodynamic synergism. epinephrine, epinephrine inhaled. [citation needed] The official in charge of the FDA review, Frances Oldham Kelsey, did not rely on information from the company, which did not include any test results. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. WebFind patient medical information for Pepto-Bismol oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Monitor Closely (1)succinylcholine increases and epinephrine decreases serum potassium. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and trazodone both increase QTc interval. Use Caution/Monitor. Select a condition to view a list of medication options. Use Caution/Monitor. amitriptyline increases and epinephrine decreases sedation. [citation needed], It is not known exactly how many worldwide victims of the drug there have been, although estimates range from 10,000 to 20,000. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Norepinephrine vs epinephrine: what's the difference. Use Caution/Monitor. [84] In 2005, Celgene received FDA approval for lenalidomide (Revlimid) as the first commercially useful derivative. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. metoprolol increases and epinephrine decreases serum potassium. desmopressin increases effects of epinephrine by pharmacodynamic synergism. Monitor Closely (1)mefenamic acid increases and epinephrine decreases serum potassium. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)haloperidol increases and epinephrine decreases sedation. NOTES: Do not share this medication with others. Consider selective beta 1 blocker (e.g., metoprolol). Modify Therapy/Monitor Closely.iloperidone increases and epinephrine decreases sedation. Many people using this medication do not have serious side effects. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. epinephrine decreases effects of iobenguane I 123 by receptor binding competition. Minor/Significance Unknown. << /Linearized 1 /L 890364 /H [ 4200 263 ] /O 279 /E 106502 /N 29 /T 888776 >> Monitor Closely (1)meperidine increases and epinephrine decreases sedation. perphenazine decreases effects of epinephrine by pharmacodynamic antagonism. Monitor Closely (2)maprotiline increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Other (see comment). Contraindicated (1)phenelzine increases effects of epinephrine by pharmacodynamic synergism. Combinations of medications can contribute to a variety of eye-related side effects as well. epinephrine, bendroflumethiazide. Use Caution/Monitor. Hypokalemia. See how UpToDate improves outcomes while reducing costs. Effect of interaction is not clear, use caution. WebPassword requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; endstream Use Caution/Monitor. epinephrine and phenylephrine PO both decrease sedation. HOW TO USE: Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you need to use epinephrine and each time you get a refill. Use Caution/Monitor. Mild side effects include: Fatigue; heavy bleeding after the delivery of a baby, induction of cervical softening and dilation in labor, stomach ulcer from aspirin or ibuprofen-like drugs, stomach ulcer from aspirin/ibuprofen-like drugs prevention. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure. epinephrine increases toxicity of lurasidone by pharmacodynamic synergism. Access your plan list on any device mobile or desktop. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. WebWeight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).Weight loss can either occur unintentionally because of malnourishment or an underlying disease, or from a Modify Therapy/Monitor Closely. Use Caution/Monitor. WebMedication Errors 6.5 Other Reporting Requirements 7 DRUG INTERACTIONS 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Renal Impairment Notable improvements to traditional LASIK surgery include Epi-LASIK and IntraLase LASIK (iLASIK). Monitor Closely (1)potassium acid phosphate increases and epinephrine decreases serum potassium. This drug is available at a higher level co-pay. Other (see comment). Form a fist around the Auto-Injector with the black tip pointing down. Avoid or Use Alternate Drug. Due to caffeine content. dihydroergotamine intranasal, epinephrine. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: irregular heartbeat, signs of infection at the injection site (such as redness that doesn't go away, warmth, swelling, or pain).Get medical help right away if you have any very serious side effects, including: chest pain, fainting, vision changes, seizures, confusion.This is not a complete list of possible side effects. Other (see comment). Monitor Closely (1)triprolidine increases and epinephrine decreases sedation. Mechanism: unknown. epinephrine and methylenedioxymethamphetamine both decrease sedation. These complications have resulted in harm to the unborn baby and mother. Monitor Closely (1)diphenoxylate hcl increases and epinephrine decreases sedation. epinephrine and xylometazoline both decrease sedation. Use Caution/Monitor.arformoterol and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor/Significance Unknown. Use Caution/Monitor.carvedilol decreases effects of epinephrine by pharmacodynamic antagonism. drospirenone increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)timolol increases effects of epinephrine by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. af!s0XEXe( Avoid or Use Alternate Drug. Use Caution/Monitor.Minor (1)epinephrine, chlorothiazide. Mechanism: unknown. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor.clomipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.epinephrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. ketorolac intranasal increases and epinephrine decreases serum potassium. Use Caution/Monitor. Contraindicated. [30] By inhibiting mEH, valproic acid and valnoctamide cause a build-up of the active metabolite, prolonging the effects of carbamazepine and delaying its excretion. This drug is available at a higher level co-pay. Use Caution/Monitor. Use Caution/Monitor. The most common side effect of replacement digestive enzymes is constipation. Use Caution/Monitor.nortriptyline increases effects of epinephrine by unknown mechanism. Mechanism: pharmacodynamic synergism. Hypokalemia. dichlorphenamide, epinephrine. prochlorperazine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)epinephrine and hydrochlorothiazide both decrease serum potassium. perphenazine increases and epinephrine decreases sedation. Serious - Use Alternative (2)desflurane increases toxicity of epinephrine by Mechanism: unknown. Effect of interaction is not clear, use caution. selegiline transdermal increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor. Interaction applies only in setting of acute lurasidone overdose. EpiPen is an injection containing epinephrine, a chemical that narrows blood vessels and opens airways in the lungs. lofepramine, epinephrine. Monitor Closely (1)methyldopa increases effects of epinephrine by unknown mechanism. Monitor Closely (3)epinephrine and salmeterol both decrease serum potassium. Monitor Closely (1)difenoxin hcl increases and epinephrine decreases sedation. Contraindicated. Monitor Closely (1)epinephrine and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. Use Caution/Monitor. Risk of hypertension and bradycardia. Effect of interaction is not clear, use caution. WebUSES: This medication is used in emergencies to treat very serious allergic reactions to insect stings/bites, foods, drugs, or other substances. Avoid or Use Alternate Drug. Contraindicated. Should I avoid certain foods while taking Zofran? However, thalidomide is a teratogenic substance, and a proportion of children born during the 1960s had thalidomide embryopathy (TE). Use Caution/Monitor. In late 1959, it was noticed that peripheral neuritis developed in patients who took the drug over a period of time, and it was only after this point that thalidomide ceased to be provided over the counter. Do not use the EpiPen if it has changed colors or has any particles in it, or if the expiration date on the label has passed. This drug is available at the lowest co-pay. maprotiline increases and epinephrine decreases sedation. Use Caution/Monitor.Minor (1)epinephrine, indapamide. restrictions. Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. cyclizine increases and epinephrine decreases sedation. [36] The German company had been established as a soap maker after World War II ended, to address the urgent market need for antibiotics. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. [2] Also, rare case reports of an auditory side effect have been made, whereby patients perceive sounds about a semitone lower than previously; this unusual side effect is usually not noticed by most people, and disappears after the person stops taking carbamazepine. Minor/Significance Unknown. flurazepam increases and epinephrine decreases sedation. Monitor Closely (2)acebutolol decreases effects of epinephrine by pharmacodynamic antagonism. WebAnabolic steroids, also known more properly as anabolicandrogenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone. Use Caution/Monitor.propranolol decreases effects of epinephrine by pharmacodynamic antagonism. Monitor Closely (2)clomipramine increases effects of epinephrine by unknown mechanism. Mechanism: unknown. Mechanism: pharmacodynamic synergism. ketotifen, ophthalmic increases and epinephrine decreases sedation. Use Caution/Monitor. People are classified as obese when their body mass index (BMI)a person's weight divided by the square of the person's heightis over 30 kg/m 2; the range 2530 kg/m 2 is defined as overweight. parecoxib increases and epinephrine decreases serum potassium. Risk of hypertension and bradycardia. triazolam increases and epinephrine decreases sedation. Use Caution/Monitor. [9][10] While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose until the medication was removed from the market in Europe in 1961. Effect of interaction is not clear, use caution. buprenorphine buccal increases and epinephrine decreases sedation. ozanimod increases toxicity of epinephrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Serious - Use Alternative (1)epinephrine and erythromycin base both increase QTc interval. Hypertension, V tach. A: Generally acceptable. dopexamine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. If these effects persist or worsen, notify your doctor promptly. Use Caution/Monitor. Minor/Significance Unknown. midazolam increases and epinephrine decreases sedation. Serious - Use Alternative (1)ketamine, epinephrine. Use Caution/Monitor. WebMedication Errors 6.5 Other Reporting Requirements 7 DRUG INTERACTIONS 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use 8.6 Renal Impairment If catecholamines are administered to treat systolic BP <75 mmHg, a dilute solution should be employed and blood pressure monitored closely. Effect of interaction is not clear, use caution. WebThalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. Use Caution/Monitor.clozapine decreases effects of epinephrine by pharmacodynamic antagonism. The dosage for children may also be based on age and weight. Use Caution/Monitor. WebHealthcare providers rely on clinical decision support systems to provide accurate, peer-reviewed patient care recommendations. Use Caution/Monitor. Consult your doctor before breast-feeding. Talk to your doctor about using ondansetron safely. You may report side effects to FDA at 1-800-FDA-1088. Use Caution/Monitor. Properly discard this product when it is expired or no longer needed. Effect of interaction is not clear, use caution. It is available as an implant placed under the skin of the upper arm under the brand names Nexplanon and Implanon, and in combination with ethinylestradiol, an estrogen, as a vaginal ring under the brand names NuvaRing and Circlet. Serious - Use Alternative (1)epinephrine and lumefantrine both increase QTc interval. dichlorphenamide and epinephrine both decrease serum potassium. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. Before using EpiPen, tell your doctor if any past use has caused an allergic reaction to get worse. Minor/Significance Unknown. WebCarbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. alfentanil increases and epinephrine decreases sedation. prescription products. Use Caution/Monitor. epinephrine and caffeine both decrease sedation. Hypokalemia. Never put your fingers over the injector tip after the safety cap has been removed. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Individuals born with TE frequently experience a wide variety of health problems secondary to their TE. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)shepherd's purse increases and epinephrine decreases sedation. WebMany people using this medication do not have serious side effects. If it does not, consult your pharmacist.The solution in this product should be clear. Additive pressor effect. Use Caution/Monitor.celiprolol decreases effects of epinephrine by pharmacodynamic antagonism. Caution if coadministered with drugs metabolized by COMT. WebWeight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).Weight loss can either occur unintentionally because of malnourishment or an underlying disease, or from a Use Caution/Monitor. Use Caution/Monitor. Richardson-Merrell was called on to perform tests and report the results. Use Caution/Monitor. trazodone, epinephrine. Do not administer these drugs until at least 7 days after each iobenguane dose. Use Caution/Monitor. Other (see comment). Comment: Due to the potential for increases in blood pressure and heart rate, atomoxetine should be used cautiously with vasopressors such as epinephrine. Additive vasospasm; risk of hypertension. Mechanism: pharmacodynamic synergism. Monitor Closely (1)epinephrine and foscarnet both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Effect of interaction is not clear, use caution. epinephrine and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. [32] Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies. Mild side effects include: Fatigue; Consult your doctor before breast-feeding. epinephrine and disopyramide both increase QTc interval. endobj Check this product visually for particles or discoloration. Monitor Closely (1)sacubitril/valsartan increases and epinephrine decreases serum potassium. May increase risk for supine hypertension. Minor/Significance Unknown. Avoid or Use Alternate Drug. It is taken by mouth.. Common side effects include headaches, muscle Use Caution/Monitor. Effect of interaction is not clear, use caution. The medication that your doctor chooses to treat your epilepsy depends on the type of seizures you have, as well as other factors such as your age and other health conditions. This medication must not be shared with others. Monitor Closely (1)buprenorphine buccal increases and epinephrine decreases sedation. [60] Meanwhile, a member of his lab, Robert D'Amato, who was looking for angiogenesis inhibitors, discovered in 1994 that thalidomide inhibited angiogenesis[61] and was effective in suppressing tumor growth in rabbits. Modify Therapy/Monitor Closely. epinephrine and chlorthalidone both decrease serum potassium. Effect of interaction is not clear, use caution. While it has been used in a number of HIV-associated conditions, such use is associated with Avoid or Use Alternate Drug. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Serious - Use Alternative (1)cabergoline, epinephrine. Use Caution/Monitor. Nevertheless, a total of 17 children with thalidomide-induced malformations were born in the US. Hypokalemia. Monitor Closely (1)melatonin increases and epinephrine decreases sedation. Risk of hypertension and bradycardia. naproxen increases and epinephrine decreases serum potassium. digoxin increases and epinephrine decreases serum potassium. It is taken by mouth.. Common side effects include headaches, muscle Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical activity in the brain. Epinephrine works quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat. Use Caution/Monitor. Necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), Reduced blood flow to digits, hands, or feet with accidental injection to those areas, Arrhythmias, including fatal ventricular fibrillation, reported, particularly in patients with underlying cardiac disease or those receiving certain drugs, There are no contraindications for life-threatening situations, Coadministration during genral anesthesia with halogenated hydrocarbons or cyclopropane, Situations where vasopressors may be contraindicated, including thyrotoxicosis, diabetes, Maternal blood pressure in excess of 130/80 mm Hg in hypertension and other cardiovascular disorders, Use caution in patients with cardiac disease, angina (especially with history of CAD) or that are receiving drugs that sensitize the myocardium; treatment may induce cardiac arrhythmias, Pulmonary edema may occur as the result of cardiac stimulation and peripheral constriction, Decreased urine output may occur as the result of renal blood vessel constriction, Use caution in cerebrovascular insufficiency, Use with caution in patients with hypertension, diabetes mellitus, thyroid disease, prostatic hypertrophy, geriatric patients, pregnancy, and previous hospitalization for asthma, Rapid IV administration, although necessary in pulesless arrest, may cause death from cerebrovascular hemorrhage or cardiac arrhythmias, Patients that are sulfite-sensitive, should still be treated during a serious allergic reaction or other emergency even if products available contain sulfites, May cause worsening of symptoms in patients with Parkinson disease, Avoid extravasation; ensure proper needle or catheter placement prior to and during infusion, Correct blood volume depletion before administering any vasopressor, Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), reported at injection site following injection for anaphylaxis; to decrease risk, do not inject into buttock; advise patients to seek medical care if they develop signs or symptoms of infection, such as persistent redness, warmth, swelling, or tenderness, at epinephrine injection site; cleansing with alcohol does not kill bacterial spores, and therefore, does not lower risk of infection, Multiple-dose vial not for ophthalmic use; contains chlorobutanol which may be harmful to corneal endothelium, Solutions must be diluted prior to intraocular use; other epinephrine products containing sodium bisulfite have been associated with corneal endothelial damage when used in the eye at undiluted concentrations (1 mg/mL), Autoinjector is to be used in conjunction with immediate medical or hospital care; more than two sequential doses of epinephrine should only be administered under direct medical supervision, During pregnancy, anaphylaxis can be catastrophic and can lead to hypoxic-ischemic encephalopathy and permanent central nervous system damage or death in the mother and, more commonly, in the fetus or neonate, The prevalence of anaphylaxis occurring during pregnancy is reported to be approximately 3 cases per 100,000 deliveries; management of anaphylaxis during pregnancy is similar to management in the general population, Epinephrine is the first line-medication of choice for treatment of anaphylaxis; it should be used in the same manner in pregnant and non-pregnant patients, In conjunction with the administration of epinephrine, the patient should seek immediate medical or hospital care, Hypotension associated with septic shock is a medical emergency in pregnancy which can be fatal if left untreated; delaying treatment in pregnant women with hypotension associated with septic shock may increase risk of maternal and fetal morbidity and mortality, Life-sustaining therapy for pregnant woman should not be withheld due to potential concerns regarding effects of epinephrine on fetus, There is no information regarding presence of epinephrine in human milk or effects on the breastfed infant or on milk production, However, due to poor oral bioavailability and short half-life, epinephrine exposure is expected to be very low in breastfed infant, Epinephrine is first-line medication of choice for treatment of anaphylaxis; it should be used in same manner for anaphylaxis in breastfeeding and non-breastfeeding patients. epinephrine and perphenazine both increase QTc interval. Monitor Closely (1)nalbuphine increases and epinephrine decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. A memorandum, rediscovered in 2010 in the archives of the FDA, shows that in 195657, as part of its in-licensing approach, Smith, Kline and French conducted animal tests and ran a clinical trial of the drug in the US involving 875 people, including pregnant women. Monitor Closely (1)epinephrine and ranolazine both increase QTc interval. Side effects may be more likely in older adults. WebProton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H + /K + ATPase, or, more commonly, the gastric proton pump) of the gastric parietal cells. Effect of interaction is not clear, use caution. Lopressor side effects (Epi-Pen); an antidepressant; an ergot medicine--dihydroergotamine, ergonovine, ergotamine, methylergonovine; or. Use Caution/Monitor.nadolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor.epinephrine and terbutaline both decrease sedation. Use Caution/Monitor. Monitor Closely (1)chloral hydrate increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. epinephrine and isoproterenol both decrease sedation. Use Caution/Monitor. Strong alpha-adrenergic effects, which cause an increase in cardio output and HR, a decrease in renal perfusion and PVR, and a variable effect on BP, resulting in systemic vasoconstriction and increased vascular permeability, Strong beta1- and moderate beta2-adrenergic effects, resulting in bronchial smooth muscle relaxation, Secondary relaxation effect on smooth muscle of stomach, intestine, uterus, and urinary bladder, Metabolized by MAO and COMT in adrenergic neuron, Metabolites: Metadrenaline, sulfate conjugates, and hydroxy derivatives of mandelic acid (inactive), Solution: Na-bicarbonate 5%, Ionosol PSL, Ionosol T/D5, Additive: Aminophylline, hyaluronidase, mephentermine, Na-bicarbonate, Not specified: Atropine, carbenicillin, diazepam, erythromycin, lidocaine, Solution: D5W, D10W, dextrose-Ringer's, dextrose-saline, NS, LR, Ringer's, Additive: Amikacin, cimetidine, dobutamine, floxacillin, furosemide, metaraminol, ranitidine, verapamil, Syringe: Caffeine, doxapram, heparin, milrinone, Y-site: Amiodarone, atracurium, bivalirudin, CaCl2, Ca gluconate, cefpirome, cisatracurium, dexmedetomidine, diltiazem, dobutamine, dopamine, famotidine, fenoldopam, fentanyl, furosemide, heparin, Hextend, hydrocortisone Na succinate, hydromorphone, inamrinone, labetalol, levofloxacin, lorazepam, midazolam, milrinone, morphine SO4, nicardipine, nitroglycerin, norepinephrine, pancuronium, phytonadione, KCl, propofol, ranitidine, remifentanil, nitroprusside, tirofiban, vasopressin, vecuronium, vitamin B/C, warfarin, Dilute epinephrine in D5W or D5W 0.9% NaCl, Administration in saline solution alone is not recommended, Add 1 mL (1 mg) of epinephrine from its ampule to 1000 mL of a D5W containing solution, Each mL of this dilution contains 1 mcg of epinephrine, Solution: 1 mg in 250 mL D5W or NS (4 mcg/mL) to make up concentration of 15-60 mL/hr (1-4 mcg/min), Correct blood volume depletion as fully as possible prior to administering any vasopressor, When, as an emergency measure, intraaortic pressures must be maintained to prevent cerebral or coronary artery ischemia, epinephrine can be administered before and concurrently with blood volume replacement, Whenever possible, administer epinephrine infusions into a large vein, Avoid using a catheter tie-in technique, because the obstruction to blood flow around the tubing may cause stasis and increased local concentration of the drug, Discard after 24 hours or if solution is discolored or contains precipitate, Epinephrine must be diluted prior to intraocular use, Dilute 1 mL of epinephrine 1 mg/mL (1:1000) in 100 to 1000 mL of an ophthalmic irrigation fluid to create an epinephrine concentration of 1:100,000 to 1:1,000,000 (10-1 mcg/mL), Use the irrigating solution as needed for the surgical procedure, After dilution in an ophthalmic irrigating fluid, inject intracamerally, Inject IM or SC into the anterolateral aspect of the thigh, through clothing if necessary, Do not administer autoinjector IV; administer only in outer thigh to ensure SC or IM administration, Do not inject into buttock, or into digits, hands, or feet, To minimize the risk of injection-related injury, instruct caregivers to hold the child's leg firmly in place and limit movement prior to and during injection when administering to young children, Discard remaining volume after dose has been administered, In conjunction with use, seek immediate medical or hospital care, COMMON BRAND NAME(S): Auvi-Q, Epipen, Symjepi, Twinject. epinephrine and moxifloxacin both increase QTc interval. Effect of interaction is not clear, use caution. Why Is My Ulcerative Colitis Getting Worse? These medications may have some side effects. Effect of interaction is not clear, use caution. Monitor Closely (1)epinephrine and furosemide both decrease serum potassium. Interaction more likely in certain predisposed pts. Additive vasospasm; risk of hypertension. Pull off the safety cap. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Use Caution/Monitor.amoxapine increases effects of epinephrine by unknown mechanism. In the UK, the British pharmaceutical company The Distillers Company (Biochemicals) Ltd, a subsidiary of Distillers Co. Ltd (now part of Diageo plc), marketed thalidomide throughout the UK, Australia and New Zealand, under the brand name Distaval, as a remedy for morning sickness. [4] It is not effective for absence or myoclonic seizures. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Hypokalemia. epinephrine and octreotide both increase QTc interval. Contraindicated. Comment: If additional adrenergic drugs are to be administered by any route, they should be used with caution because the sympathetic effects of indacaterol may be potentiated. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)oxytocin increases effects of epinephrine by pharmacodynamic synergism. celecoxib increases and epinephrine decreases serum potassium. Monitor Closely (1)drospirenone increases and epinephrine decreases serum potassium. Mechanism: pharmacodynamic synergism. promethazine increases and epinephrine decreases sedation. Monitor Closely (1)parecoxib increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. epinephrine and formoterol both decrease sedation. Use Caution/Monitor. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. epinephrine, chlorthalidone. tapentadol increases and epinephrine decreases sedation. In the US, the label for carbamazepine contains warnings concerning: Common adverse effects may include drowsiness, dizziness, headaches and migraines, motor coordination impairment, nausea, vomiting, and/or constipation. 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