And your symptoms will come back. These vibrations are transported across the water tank, enveloping the medication with the water serving as a coolant. Asthma treatment usually has two parts. Take normal, calm breaths as much as you can. Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. Case of 48 Irrigation Solutions for use in The Irrigation of Devices. 142.85 if Purchased Separately. The medications in all of these bronchodilator inhalers are said to work for about 4-6 hours after you use them. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Throw away any unopened, unused medicine after the expiration date. These intense vibrations help in generating liquid medication columns by producing smaller particles. Short-acting beta agonists are common rescue medicines. Regulation of endogenous ENaC functional expression by CFTR and ?F508-CFTR in airway epithelial cells. Many people using this medication do not have serious side effects. It While these nebulizers offer many of the conveniences of ultrasonic nebulizers, the mesh can sometimes get clogged or break- putting your asthma control in jeopardy. Mucus causes small airway obstruction and airway hyperresponsive which is difficult to remove. Fahy JV, Locksley RM. Ion channels have been the center of many studies aiming to understand asthma pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. If you havent been taking your inhaler correctly you will have been missing out on the full dose of asthma medicine. The wind accompanying rainstorms can also stir up and spread particles. HHS Vulnerability Disclosure, Help Cromolyn prevents your body from releasing substances involved in inflammation. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. 8600 Rockville Pike [25] Mucus hydration is set by the volume of liquid present on the airway surfaces, which may be modified by active ion transport processes in both the superficial epithelium and glands. Method: All 35 patients were under correct treatment according to GOLD guidelines for at least two weeks prior to the start of the study. Albuterol sulfate inhalation solution (0.083%) contains no sulfiting agents. Recent research has focused on epithelial electrolyte disorder. Drug lessons: Minerals and electrolytes, A puffer with spacer is also easier, faster and cheaper, is much more portable, and reduces the potential for side-effects. They may also be used by GPs in medical centres or clinics. The most common type of inhaler involves inhaling a given amount of medication using a mouthpiece. The calm winds of summer and strong sun do little to disperse these particles, leaving smog to settle like clouds. Douros K, Loukou I, Doudounakis S, Tzetis M, Priftis KN, Kanavakis E. Asthma and pulmonary function abnormalities in heterozygotes for cystic fibrosis transmembrane regulator gene mutations. Maybe youve caught a cold, or its pollen season and your hay fevers bad. Keep all medications away from children and pets. Keep this medication in the container it came in, tightly closed, and out of reach of children. Which is why hay fever often occurs during summer, when its time to cut hay. Let us know your thoughts on Breath of Fresh Air! Talk to your pediatrician regarding the use of this medicine in children. will also be available for a limited time. List of Nebulizer Medications and IngredientsAlbuterol and Levalbuterol. Albuterol (AccuNeb) and levalbuterol (Xopenex) are closely related medications used for quick relief of asthma symptoms.Ipratropium Bromide. Ipratropium bromide is another type of bronchodilator that can be delivered with a nebulizer for relief of asthma flareups.Budesonide. Cromolyn Sodium. Warning and Precautions. The researchers also found that allergic is associated with the change of intracellular Na+ homeostasis. Copyright 2022 Elsevier Inc. All Rights Reserved. [86] revealed the potential relationship between CFTR gene mutation in Asian patients (Singaporean Chinese) with severe asthma. It should not be used for medical advice, diagnosis or treatment. [75] Britton et al. 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Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells. [78] reported that levels of Na+ influx into isolated peripheral blood mononuclear cells (PBMCs) were associated with the levels of airway responsiveness. Ballard ST, Spadafora D. Fluid secretion by submucosal glands of the tracheobronchial airways. One mechanism of atomization inhalation drug therapy is increasing the expression of ENaC. Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells. [12] Changes in ion transport have also been implicated in asthma pathogenesis. Nebulization is usually recommended when a person finds difficulty while using an inhaler or in a condition where the person needs to inhale large dose of medicines directly into the lungs. Acute effects of cigarette smoke extract on alveolar epithelial sodium channel activity and lung fluid clearance. Agrawal A, Agrawal KP, Ram A, Sondhi A, Chhabra SK, Gangal SV, et al. French scientist Sales-Girons is credited with this mind-blowing invention which helped treat Asthma patients.This nebulizer was a rough version which was later in 1864 modified and a new stream is driven nebulizer was invented. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. The pathophysiology of asthma. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. The liquid mist is created using compressed air and the medication is then inhaled into the lungs. (4X 4Fl. This is not a complete list of possible side effects. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. You can also use cromolyn sodium in a nebulizer. Navage Nasal Care Deluxe Bundle Nose Cleaner, 20 SaltPods, Triple-Tier Countertop Caddy, & Travel Bag. The battery-driven handheld versions simply arent as effective. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Do not puncture the aerosol canister, and do not discard it in an incinerator or fire. Bronchiolitis is a common viral lung infection in infants. Therefore, dysfunction in ion channels changes ASL and the amount of mucus in airway epithelium. Keep in the original container until ready to use. [39,40,41], Asthma is associated with airway hyperresponsiveness (AHR), which leads to recurrent episodes of shortness of breath, coughing, and wheezing. Read the manufacturers instructions for care of your nebulizer. However, the studies in Barcelona found no obvious correlation between both. Sodium chloride is an ionic compound that is made up of the sodium cation and the chloride anion. When dissolved in water or some other polar solvent, this compound is known to dissociate into the Na+ and the Cl- ions. Therefore, sodium chloride is not a nonelectrolyte (it is an electrolyte). Its effect lasts for approximately 12 hours and, therefore, should not be used more than twice per day. Anyone can be given medicine through a nebuliser. Molina R, Han DY, Su XF, Zhao RZ, Zhao M, Sharp GM, et al. Nebuliz - 25 Single-Dosage (5 ml) Sterile Solution Vials of Hypertonic Saline (Sodium Chloride) 7% and Sodium Hyaluronate with Hyaluronic Acid for Inhalation Therapy, Preservative-Free, Sandford A. It is an alternative to inhaled corticosteroids. Read Also: How To Treat Asthma Without Inhaler. However, it is highly recommended to consult a doctor before using it. So far, the mechanism by which sodium is increasing inflammation is unknown. Crolom, Gastrocrom, Intal, Nasalcrom, Opticrom. If you are constantly on the move then a smaller model that you can fit in your bag or hold in your hand will be more convenient. Your recently viewed items and featured recommendations, Select the department you want to search in. maltipoo puppies for sale in georgia under $500. Even if youve been taking an inhaler for years, its easy to slip into bad habits. Salt attracts water into the airways, which thins the mucus, making it easier to cough out. This list may not describe all possible interactions. Nebulizers are often used in an emergency setting because they deliver the medication faster. Daniel More, MD, is a board-certified allergist and clinical immunologist. Tyrrell J, Tarran R. Gaining the upper hand on pulmonary drug delivery. Boucher RC. US residents can call their local poison control center at 1-800-222-1222. Do not share this medicine with others. [63], Epithelial sodium channel in airway epithelia is mainly regulated by glucocorticoids (GCs). It suggests that dysregulation of this epithelial response may provide a clue to severe airway mucus plugging in fatal asthma. It may be a few hours before your doctor feels happy to stop nebuliser treatment and move you back onto a reliever inhaler and spacer. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. [64,65] ENaC can also be controlled by intracellular factors including pH, lipids, and protein kinase A (PKA),[66,67,68] which may affect the number of ENaCs inserted into the plasma membrane as well as affect gating. Tarran R, Button B, Boucher RC. In particular, unless you have a known serious heart condition, there is no danger to your heart when using bronchodilator inhalers with this frequency for a short period of time. Recent evidence suggests that dietary sodium can potentiate exercise-induced bronchoconstriction (EIB). Devereux G, Beach JR, Bromly C, Avery AJ, Ayatollahi SM, Williams SM, et al. Holgate ST. If you have ever been to the Emergency Department of a hospital for your asthma, you know that bronchodilator medications can be given safely as often as every 20 minutes for quick relief of an asthma attack. Store at room temperature away from light and heat. In addition to the CFTR, Cl channel-gating depends on many factors, including transmembrane voltage, cell swelling, cross-linking with signal molecules, cell phosphorylation residue or ATP combination and hydrolysis caused by various ions and protein kinase. Some dosage forms listed on this page may not apply to the brand name Sodium Chloride, Inhalation. Gotshall et al. Although the role of dietary sodium in the modulation of asthma, its associated AHR is unclear. Visit your health care professional for regular checks on your progress. The net result of airway dehydration is the activation of resident airway inflammatory cells (e.g., mast cells) and increasing the release of inflammatory mediators (e.g., histamine, leukotrienes, and prostaglandins) that trigger contraction of the ASM. Epithelial cell mucus production is increased in asthma,[3] and plugging of the airways with mucus is prominent and sometimes fatal for severe asthma exacerbations. Although anyone can get COPD, even non-smokers, cigarettes are responsible for about 90 percent of cases. Accessibility The conducting airways are the primary interface between the extracellular environment and the lung, which play a major role in host defense. Boulet LP, FitzGerald JM, Reddel HK. Save 22.90. In our online shop we offer the most diverse portfolio of bioresources for researchers from academia & industry. Learn more If you live with: Nebulisers can also be used in palliative care and to give drugs to very young children, such as those with viral . [79] reported that low-salt diets improved and high-salt diets worsened postexercise pulmonary function in individuals with diagnosed EIB (or exercise-induced asthma) as measured by spirometry. If an asthma patient finds that nebulized therapy is more effective than inhalers, the nebulizer should be used in a room that is isolated from other household members. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA. How To Treat Asthma Attack Without An Inhaler, What Sounds Might You Hear During An Asthma Exacerbation, Can You Buy Asthma Inhalers Over The Counter, How Does Asthma Impact The Respiratory System, Corticosteroid for relieving inflammation, Disconnect the nebulizer cup tubing from the compressor after each treatment, Open the cup and wash the cup and mouthpiece according to the instructions for your machine, Rinse the cup and the mask or mouthpiece in a solution of vinegar and water. Smog tends to be worse during the summer as it creates ozone at the ground level as car exhausts and fumes spread chemicals into the air. At the pathophysiological level, asthma results from complex biological interactions between different cell types, both resident (i.e., epithelial and smooth muscle cells) and circulating (mainly immune cells), and environmental factors such as allergens, infections, and tobacco smoke. Do not double the dose to catch up. Take all of your medicine as directed even if you think you are better. In a well-designed follow-up study (double-blinded placebo-controlled trial), it was revealed that a low-salt diet attenuates some of the inflammation associated with EIB (e.g., attenuation of increases in sputum levels of eosinophil cation protein, IL-1, and IL-8 but not cysteinyl leukotrienes C4-E4, leukotriene B4, or prostaglandin D2-methoxime). The new coronavirusability to wreak havoc in the lungs is raising a lot of concerns and questions from my patients. The data from studies examining airway function in the context of asthma and dietary salt intake demonstrate a weak association between salt intake and increased airway reactivity and are controversial. At the same time, blood pH value increases, serum lactic acid levels decrease, which are beneficial for the body recover. The most common side effects of nebulizer treatment are rapid heartbeat, jitteriness and anxiety. This survey is being conducted by the WebMD marketing sciences department. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. Erle DJ, Zhen G. The asthma channel? However, you should not flush this medication down the toilet. The most common side effects are: If these side effects occur and do not get better, or they become disruptive, talk with a doctor as soon as possible about ways to manage or avoid them. It can also lead to recurrent episodes of wheezing, chest tightness, and cough. Trevor JL, Deshane JS. For suspension for inhalation: For bronchial asthma: Adults and children 8 years of age and older1000 to 2000 micrograms (mcg) mixed with enough sterile sodium chloride solution for Ji HL, Chalfant ML, Jovov B, Lockhart JP, Parker SB, Fuller CM, et al. The National Library of Medicine The information exchange between airway epithelial cells and immune inflammatory cells may play an important role in the local mucosal regulation of the immune system. Its the simplest nebulizer for everyone and anyone to use. Otherwise, call a poison control center right away. Do not use double or extra doses. A few patients have told me they stopped their inhaled corticosteroid medication because they were concerned that the steroids would suppress their immune systems. Therefore, the simple answer to the question above is that it is safe to use these inhalers 4-6 times per day. Other common side effects may include a salty taste or slight burning or irritation in your mouth. Policy, Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Visitation, mask requirements and COVID-19 information. DeltaF508 heterozygosity in cystic fibrosis and susceptibility to asthma. [11] Similar pathology was seen with ASL dehydration in mice with transgenic overexpression of the epithelial sodium channel (ENaC). Lu J, Li C, Shi C, Balducci J, Huang H, Ji HL, et al. How long you need to be on a nebuliser depends on how you respond to treatment, and how severe your asthma attack is. Wash this with hot water and mild liquid dish soap. Nebulized therapy, which is often called a breathing treatment, is an especially convenient way to administer asthma medication to children or others who find it challenging to use an inhaler. Did you start a new job, or go on holiday? This medication is used with a special machine called a nebulizer that changes the solution to a fine mist that you inhale. FOIA Salbutamol can be used by adults and children of all ages. Its a short-acting drug that provides almost instant relief during an asthma attack. Federal government websites often end in .gov or .mil. Clean Nose, Healthy Life! The first involves fast-acting medication for flare-ups. Pseudo-hypoaldosteronism patients have decreased sodium reabsorption function and increased watery secretion, 99m-Tc scanning suggests mucosa of the abnormal-lung cilia showed greater clearance rate. The development of allergic inflammation. The airway epithelium shows ENaC/CFTR associated with asthma pathophysiology [Figure 1]. Sometimes, if you have not responded well to these spaced doses, you may be given back to back or continuous nebulisation, and other medicines may be added to the nebuliser, such as ipratropium. Nebulizer solution used for allergies control or exercising-brought on bronchospasm, but is not a favored treatment. SODIUM CHLORIDE (SOE dee um KLOOR ide) nebulizer solution is used to help loosen mucus in the lungs or to help deliver medications to the lungs to improve breathing in patients with breathing problems. A peak flow meter is a handheld device that measures the peak expiratory flow rate , or how much air you can forcibly push out of your lungs at a particular time. Danahay H, Jackson AD. You May Like: Do Chihuahuas Take Away Asthma. Nebulizers or breathing machines, as they are often referred to by patients, are devices that allow you to aerosolize liquid asthma medication and inhale it directly into your lungs as a mist. Discover more about the small businesses partnering with Amazon and Amazons commitment to empowering them. Ion channels have been the center of many studies aiming to understand asthmatic pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. Ulinastatin can be used to reverse the inhibition of ENaC-mRNA and protein expression due to the lack of oxygen, and has some relevance with the concentration. All the latest research shows that a puffer with spacer works just as well as a nebuliser for treating asthma symptoms, including during an asthma flare-up. Even those with severe asthma, who regularly use a nebuliser at home as advised by their asthma specialist, should get medical help quickly if they need to use it for an asthma attack. When used Sodium Chloride Nebulizer Solution Generic name: Sodium Chloride Nebulizer Solution [ SO-dee-uhm-KLOR-ide ] Brand names: HyperSal, Nebusal, PulmoSal Drug classes: Minerals and electrolytes, Miscellaneous respiratory agents Medically reviewed by Drugs.com. Some have suggested that lysophosphatidylcholine (LPC) may be a likely candidate. But they can only do this if you take them every day. Almost everyone who has asthma or COPD is prescribed a bronchodilator inhaler or reliever inhaler to help their breathing. travel across the plasma membrane and epithelial salt transport, it plays an important role in regulating water flow and ion concentration, and adjusting the pH value of mucus. Although the role of dietary sodium in the modulation of asthma, its associated AHR is unclear. [37,38], Cystic fibrosis transmembrane conductance regulator as cAMP dependent Cl channel, also controls the other type of ion channels, including epithelial Cl and Na+ channels, and ATP transporter. The terms used in the literature search were: (1) ENaCs; cystic fibrosis (CF) transmembrane conductance regulator (CFTR); asthma/asthmatic, (2) ENaC/sodium salt; CF; asthma/asthmatic, (3) CFTR/chlorine ion channels; asthma/asthmatic, (4) ENaC/sodium channel/scnn1a/scnn1b/scnn1g/scnn1d/amiloride-sensitive/amiloride-inhibtable sodium channels/sodium salt; asthma/asthmatic, lung/pulmonary/respiratory/tracheal/alveolar, and (5) CFTR; CF; asthma/asthmatic (ti). Sodium chloride is taken as a typical ionic compound. Compounds like this consist of a giant (endlessly repeating) lattice of ions. So sodium chloride (and any other ionic compound) is described as having a giant ionic structure. You should be clear that giant in this context doesn't just mean very large. Canada residents can call a provincial poison control center. 12 Medicines That Could Help. Corticosteroids reduce inflammation. RSV Hypertonic Saline 7% + Hypertonic Saline (Sodium Chloride) 7% and Sodium Hyaluronate with Hyaluronic Acid, 25 vials of 5ml/0.18 Fl Oz Each -, NAVEH PHARMA RSV Hypertonic Saline 3% + Hypertonic Saline (Sodium Chloride) 7% and Sodium Hyaluronate with Hyaluronic Acid , 25 vials of 5ml/0.18 Fl Oz Each -, NAVEH PHARMA RSV Hypertonic Saline Solution 7% + RSV Hypertonic Saline 3% - 25 Units of 5ml/0.18 Fl Oz Each, Natural Solution Ceramic Salt Inhaler with 2 Himalayan Pink Salt Refills, Relief Breathing Congestion, White, ADDIPAK Unit Dose Solutions - 15ml (48 ea / Box), Essential Oxygen, Food Grade Hydrogen Peroxide, 8 + 32 fl oz, Natural Cleaner, 3%, 1 - 8 fl oz spray and 1 - 32 fl oz bottle, Refill, HP (Pack of 2), Kisangel 10pcs Saline Solution for Inhalation Toddler Baby Eyelid Eyelash Cleansing Solution Easy Baby Nose Cleaner Infants Mintron Nasal Congestion, Navage Nasal Care Starter Bundle: Navage Nose Cleaner, 20 SaltPods, Plus Bonus 10 SaltPods, Squip Nasaline Salt 50 Pre-mixed saline packets. [24] The rate of mucociliary clearance (MCC) is strongly influenced by the hydration state of the ASL and mucus layers. For babies and small children, different size facemasks can be used. Hospitals and other facilities are being advised to reduce their use of nebulizers to reduce spread of the new coronavirus. You can also contact the nebuliser company or manufacturers for advice if you need help with the device itself. Wine JJ, Joo NS. The kind of asthma medication prescribed also determines which nebulizer can be used. How the airway smooth muscle in cystic fibrosis reacts in proinflammatory conditions: Implications for airway hyper-responsiveness and asthma in cystic fibrosis. This ultimately generates tiny droplets like an aerosol. nebulizer was invented. Get emergency medical help if you have any of these signs of an allergic reaction: ; difficult breathing; swelling of your face, lips, tongue, or throat. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. The .gov means its official. Partners Asthma Center. It delivers medication easier compared to an inhaler. ;; Water in a nebulizer for cough, stuffy nose, lung congestion, and bronchitis is many times recommended to use, especially for people who do not want to use medications for respiratory problems. Do not store in the bathroom. In addition, to elucidate the mechanism of this effect, investigations will need to pay more attention to salt sensitive airway obstruction in the future. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Bartlett JA, Fischer AJ, McCray PB Jr. Innate immune functions of the airway epithelium. Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, et al. This product should be clear and colorless. Squip Nasaline Salt 50 Pre-mixed saline packets, 555251BX - AirLife Modudose Unit Dose Saline, 3mL 0.9% Inhalation, 0.10 Fl Oz Each, 100 Count (Pack of 1), Aqua Naina - Preservative Free Sterile Saline Solution - Unisol 4 Replacement - Contact Solution for Cleaning, Rinsing and Storing Soft Contact Lenses. High-serum LPC levels have been associated with increased asthma severity and increased accumulation of Na+ in PBMCs and leukocytes. These results indicate that the coordinate increase in fluid and mucin secretion in Th2-driven airway inflammation may provide a protective mechanism to promote mucus clearance and prevent airway mucus plugging in the presence of mucus overproduction in allergic airway disease. For suspension for inhalation: For bronchial asthma: Adults and children 8 years of age and older1000 to 2000 micrograms (mcg) mixed with enough sterile sodium chloride solution for inhalation, if necessary, to make 2 to 4 milliliters (mL). [84] conducted a multinational analysis in 1113 obligate CFTR gene mutation heterozygotes and 688 controls and found that prevalence of asthma in CF heterozygotes was 9.6% that was similar with that reported by Dahl et al. If youre having an asthma attack or having trouble breathing, just a few minutes can feel like an eternity, which is why delivering respiratory medicines via a nebulizer can give you peace of mind much more quickly. All rights reserved. It is not known whether sodium chloride passes into breast milk or if it could harm a nursing baby. CFTR and ENaC, as an important channel for epithelial fluid and electrolyte transport, play a key role in the AHR diseases. Talk to your doctor about your situation and your needs, then select the machine that suits you best. Therefore, they are perfect for traveling, especially with children. Pochynyuk O, Bugaj V, Stockand JD. 7. This medication may also be used to dilute other medications inhaled through a nebulizer. How Often Can You Use A Nebulizer For Asthma, bronchodilator inhaler or reliever inhaler, Can You Be A Commercial Pilot With Asthma, Can You Buy Asthma Inhalers Over The Counter. Albuterol may not be suitable for some people. Due to its help of the Cl and HCO3 The latest research shows usinga spacer reliever inhaleris easier and just as effective. Regulation of airway surface liquid volume by human airway epithelia. Well explain what you need to know about common asthma attack triggers, so you can do your best to prevent symptoms from interrupting your everyday life. If you have any unusual effects, contact your doctor or pharmacist promptly. Effects of rhinovirus infection on the expression and function of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel in human nasal mucosa. These results suggest that Th2-mediated fluid secretion may improve airway surface hydration and clearance of mucus that is hypersecreted in allergic airway diseases such as asthma. Once your breathing is better, it may be possible for you or your child to use salbutamol less often. [70,71], Sodium-water transport with ENaC is a process of energy consumption, in case of lack of oxygen, it can increase the intracellular reactive oxygen content, the shortage of the energy will bring down the role of ENaC. Mylan has sodium chloride inhalation solution available. Stay tuned. 1Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing 100020, China, 2Department of Cellular and Molecular Biology, Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler Texas 75708, USA. Generic call: Sodium Chloride Nebulizer Solution [ SO-dee-uhm-KLOR-ide ] Brand names: HyperSal, Nebusal, PulmoSal. Although the role of dietary sodium in the modulation of asthma, its associated AHR is unclear. Downs CA, Trac DQ, Kreiner LH, Eaton AF, Johnson NM, Brown LA, et al. Impaired MCC, together with CFTR-related changes in the airway surface microenvironment, leads to a progressive cycle of infection, inflammation, and declining lung function. 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